Available Positions       
 
PUBLICATIONS
     

A complete list of our publications can be found at : http://www.ncbi.nlm.nih.gov/sites/myncbi/h..brown.1/bibliography/41176006/public/?sort=date&direction=descending

Selected Reviews and Chapters:

Brown HA, Thomas PG, Lindsley CW. (2017) Targeting phospholipase D in cancer, infection and neurodegenerative disorders. Nature Rev. Drug Discovery. Epub ahead of print February 17, 2017. doi: 10.1038/nrd.2016.252.

McDonald JG, Ivanova PT, Brown HA. (2015) Approaches to lipid analysis. In "Biochemistry of  Lipids, Lipoproteins, and Membranes". 6th Ed. N.D. Ridgway and R. McLeod (Eds). Elsevier. ISBN 9780444634382. Available to order at: http://store.elsevier.com/product.jsp?isbn=9780444634382&pagename=search

Bruntz RC, Lindsley CW, Brown HA. (2014) Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol. Rev. 66(4): 1033-1079. PMC 4180337

Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA. (2014) Chemical modulation of glycerolipid signaling and metabolic pathways. Biochim. Biophys. Acta - Molec. Cell Biol. Lipids 1841: 1060-1084. PMC 4069240

Milne SB, Mathews TP, Myers DS, Ivanova PT, and Brown HA. (2013) Sum of the parts:mass spectrometry-based metabolomics. Biochemistry 52(22): 3829-3840 PMC 3674197

Brown HA (2012) Lipidomics: When apocrypha becomes canonical. Current Opinion in Chemical Biology 16(1-2): 221-226 PMC 3328648

Lindsley CW and Brown HA. (2012)  Phospholipase D as a therapeutic target in brain disorders. Neuropsychopharmacology Reviews 37(1): 301-302. PMC 3238067

Selvy PE, Lavieri RL, Lindsley CW, and Brown HA. (2011)  Phospholipase D-enzymology, functionality, and chemical modulation. Chemical Reviews –Lipid Biochemistry, Metabolism and Signaling 111(10): 6064-6119. PMC 3233269

Brown HA and Marnett MJ. (2011) Introduction to lipid biochemistry, metabolism and signaling. Chemical Reviews –Lipid Biochemistry, Metabolism and Signaling 111(10): 5817-5820. PMID 21951202

Myers DS, Ivanova PT, Milne SB, and Brown HA. (2011) Quantitative analysis of glycerophospholipids by LC-MS: acquisition, data handling and interpretation. Biochim. Biophys. Acta - Molec. Cell Biol. Lipids 1811: 748-757. PMC 3292045

Brown HA and Murphy RC. (2009)  Working towards an exegesis for lipids in biology. Nature Chemical Biology 9: 602-606. PMC 3785062

Ivanova PT, Milne SB, Myers DS, and Brown HA. (2009) Lipidomics: a mass spectrometry based systems level analysis of cellular lipids. Current Opinion in Chemical Biology 13(5-6): 526-531. PMC 2787871

Brown HA. (2008) New mechanism for a classic folate inhibitor.  Nature Chemical Biology 10: 581-582 PMID 18800042

Ivanova PT, Milne SB, Byrne MO, Xiang Y, and Brown HA. (2007) Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry. In Methods in Enzymology 432, Lipidomics and Bioactive Lipids: Mass spectrometry based lipid analysis. Ed. by H. Alex Brown. Elsevier. pp. 21-57. PMID 17954212

Brown HA, Henage LG, Preininger AM, Xiang Y, and Exton JH. (2007) Biochemical Analysis of Phospholipase D. In Methods in Enzymology 434, Lipidomics and Bioactive Lipids: Lipids and Cell Signaling.  Ed. by H. Alex Brown. Elsevier. pp. 49-87. PMID17954242


2016

Tribble EK, Ivanova PT, Grabon A, Alb JG, Jr., Faenza I, Cocco L, Brown HA, Bankaitis VA. (2016) Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts. J. Lipid Res. 57(8): 1492-1506. PMC 4959864

Sohn M, Ivanova PT, Brown HA, Toth DJ, Varnai P, Kim YJ, Balla T. (2016) Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism in ER-PM and ER-Golgi junctions. Proc. Natl. Acad. Sci. USA 113(16): 4314-4319. PMC 4843478

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2015

Ivanova PT, Myers DS, Milne SB, McClaren JL, Thomas PG, Brown HA. (2015) Lipid composition of viral envelope of three strains of influenza virus - not all viruses are created equal. ACS Infect. Diseases 1(9): 399-452. PMC 4593503

Taylor HE, Simmons GE, Mathews TP, Khatua AK, Popik W, Lindsley CW, D'Aquila RT, Brown HA. (2015) Phospholipase D1 couples CD4+T cell activation to c-Myc-dependent deoxyribonucleotide pool expansion and HIV-1 replication. PLoS Pathog. 11(5): e1004864. doi:10.1371/journal.ppat.1004864. PMID 26020637

Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann MJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, Armando AM, Milne SB, Mathews TP, Armstrong MD, Li C, Melvin WV, Clements RH, Washington MK, Mendonsa AM, Witztum JL, Guan Z, Glass CK, Murphy RC, Dennis EA, Merrill AH, Jr., Russell DW, Subramaniam S, Brown HA. (2015) Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J. Lipid Res. 56(3): 722-736. PMC 4340319

Mathews TP, Hill S, Rose KL, Ivanova PT, Lindsley CW, Brown HA. (2015) Human phospholipase D transiently regulates pyrimidine biosynthesis in malignant gliomas. ACS Chem. Biol. 10(5): 1258-1268. PMC 4433586

Spencer CT and Brown HA. (2015) Biochemical characterization of a Pseudomonas aeruginosa phospholipase D. Biochemistry 54(5): 1208-1218. PMC 4337821

Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim T deA., Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM. (2015) The TMAO-generating enzyme flavin monooxigenase 3 is a central regulator of cholesterol balance. Cell Reports 10(3): 326-338. PMC 4501903

Mitchener MM, Hermanson DJ, Shokley EM, Brown HA, Lindsley CW, Reese J, Rouzer CA, Lopez CF, Marnett LJ. (2015) Competition and allostery govern substrate selectivity of cyclooxygenase-2. Proc. Natl. Acad. Sci. USA 112(40): 12366-12371. PMC 4603459

O'Reilly MC, Scott SA, Daniels JS, Morrison R, Engers JL, Oguin T, Thomas P, Brown HA, Lindsley CW. (2015) A next generation PLD2 inhibitor with improved physiochemical properties and DMPK profile for translational in vivo. Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US). PMID 2583490

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2014

Oguin TH, Sharma S, Stuart AD, Duan S, Scott S, Jones CK, Daniels JS, Lindsley CW, Thomas PG, Brown HA. (2014) Phospholipase D facilitates efficient entry of influenza virus allowing escape from innate immune inhibition. J. Biol. Chem. 289(37): 25405-25417. PMC 4162146

Bruntz RC, Taylor HE, Lindsley CW, Brown HA. (2014) Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells. J.  Biol. Chem. 289(2): 600-616. PMC 3887188 * Article Feature on the issue COVER and PAPER OF THE WEEK. See first-author profile at http://www.jbc.org/content/289/2/600/suppl/DCAuthor profile

O'Reilly MC, Scott SA, Brown HA, Lindsley CW. (2014) Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition. Bioorg. Med. Chem. Lett. 24(24): 5553-5557. PMID 25466173

Scott SA, Spencer CT, O'Reilly MC, Brown KA, Lavieri RL, Cho C-H, Jung D-I, Larock RC, Brown HA, Lindsley CW. (2014) Discovery of desketoraloxifene analogs as inhibitors of mammalian, Pseudomonas aeruginosa and NAPE phospholipase D enzymes. ACS Chem. Biol. 10(2): 421-432. PMC 4336625

O'Reilly MC, Oguin TH,3rd, Scott SA, Thomas PG, Locuson CW, Morrison RD, Daniels JS, Brown HA, Lindsley CW. (2014) Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad spectrum antiviral activity against influenza strains. ChemMedChem 9(12): 2633-2637 PMID 25210004

Cipriano R, Bryson BL, Miskimen KLS, Bartel CA, Hernandez-Sanchez W, Bruntz RC, Scott SA, Lindsley CW, Brown HA, Jackson MW. (2014) Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B. Oncogene 33(25): 3298-3306. PMC 3923847

Ren J, Pei-Chen Lin C, Pathak MC, Temple BR, Nile AH, Mousley CJ, Duncan MC, Eckerd DM, Leiker TJ, Ivanova PT, Myers DS, Murphy RC, Brown HA,Verdaasdonk J, Bloom KS, Ortlund EA, Neiman AM,Bankaitis VA. (2014) A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis. Mol. Biol. Cell 25(5): 712-727. PMC 3937096

Leamy AK, Egnatchik RA, Shiota M, Ivanova PT, Myers DS, Brown HA, Young JD. (2014) Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells. J. Lipid Res. 55(7): 1478-1488. PMC 4076085

Faust JE, Manisundaram A, Ivanova PT, Milne SB, Summerville JB, Brown HA, Wangler M, Stern M, McNew JA. (2014) Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster. PLoS ONE 9(6): e100213. doi:10.1371/journal.pone.0100213. PMC 4063865


2013

Scott SA, Xiang Y, Mathews TP, Plumley HC, Myers DS, Armstrong MD, Tallman KA, O’Reilly MC, Lindsley CW, Brown HA. (2013) Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation. J.  Biol. Chem. 288(28): 20477-20487.  PMC 3711313

Shibata M, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski C, Maurya MR, Kaikkonen M, Lam M, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CRH, Sullards MC, Murphy RC, Merrill Jr. AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. (2013) 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. J. Biol. Chem. 288(50): 35812-35823. PMC 3861632

Tallman K, Armstrong MD, Milne SB, Marnett LJ, Brown HA, Porter NA. (2013) Cobalt carbonyl complexes as probes for alkyne-tagged lipids.  J. Lipid Res. 54: 859-868. PMC 3617960

O’Reilly MC, Scott SA, Brown KA, Oguin TH 3rd, Thomas PG, Daniels JS, Morrison R, Brown HA, Lindsley CW. (2013) Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-triazaspiro[4.5]decane core: discovery of ML298 and ML299 that decrease invasive migration in U87-MG glioblastoma cells. J. Med. Chem. 56(6): 2695-2699. PMC 3632306

Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy  RC, Russell DW, Dennis EA, Subramaniam S. (2013) Analysis of inflammatory and lipid metabolic networks across RAW264.7  and thioglycolate-elicited macrophages. J. Lipid Res. 54(9): 2525-2542. PMC 3735949

Shulga YV, Loukov D. Ivanova PT, Milne SB, Myers DS, Hatch GM, Umeh G, Jalan D, Fullerton MD, Steinberg GR, Topham MK, Brown HA, Epand RM. (2013) Diacylglycerol kinase Delta promotes lipogenesis. Biochemistry 52(44): 7766-7776. PMC 3864584

Thomas G, Betters JL, Lord CC, Brown AL, Marshall S, Ferguson D, Sawyer J, Davis MA, Melchior J, Blume LC, Howlett AC, Ivanova PT, Milne SB, Myers DS, Mrak I, Leber V, Heier Ch, Taschler U, Blankman JL, Cravatt BF, Lee RG, Crooke RM, Graham MJ, Zimmermann R, Brown HA, Brown JM. (2013) The serine hydrolase ABHD6 is a critical regulator of the metabolic syndrome. Cell Reports 5(2): 508-520. PMC 3833083

Kim S-H, Scott SA, Bennett MJ, Carson RP, Brown HA, Ess KC. (2013) Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency. PLoS Genetics 9(6): e1003563. PMC 3681725

Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St.Croix B. (2013) Essential regulation of lung surfactant homeostasis by the orphan G-protein coupled receptor GPR 116. Cell Reports 3(5): 1457-1464. PMC 3695742

Moore J, Li S, Myers DS, Milne SB, Brown HA, Shaw W. (2013) Standardization and quantification of lysophosphatidic acid compounds by normal-phase and reverse-phase chromatography-tandem mass spectrometry. In Lysophospholipid Receptors:Signaling and Biochemistry. John Wiley &Sons, Inc. Ed. by J. Chun, T. Hla, S. Spiegel, W. Moolenaar, pp 137-152.

Meszaros P, Klappe K, van Dam A, Ivanova PT, Milne SB, Myers DS, Brown HA, Permentier H, Hoekstra D, Kok JW (2013) Long term myriocin treatment increases MRP1 transport activity. Int. J. Biochem. Cell Biol. 45(2): 326-334. PMC 3826170


2012

Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Li AC, Ley K, Tsimikas S, Fahy E, Subramaniam S, Quehenberger O, Russell, DW, Glass CK (2012). Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1): 138-152. PMC 3464914

Li JZ, Huang Y, Karaman R, Ivanova PT, Brown HA, Roddy T, Castro-Perez J, Cohen JC, and Hobbs HH (2012). Chronic overexpression of PNPLA3I148M in mouse liver causes hepatic steatosis. J. Clin. Invest. 122(11): 4130-4144. PMC 3484461

Cipriano R, Graham J, Miskimen K, Bryson BL, Bruntz RC, Scott SA, Brown HA, Stark GR, and Jackson MW (2012). FAM83B mediates EGFR- and RAS-driven oncogenic transformation. J. Clin. Invest. 122(9): 3197-3210. PMC 3428078

Kumari M, Schoiswohl G, Chitraju C, Paar M, Cornaciu I, Rangrez AY, Wongsiriroj N, Nagy HM, Ivanova PT, Scott SA, Knittelfelder O, Rechberger GN, Birner-Gruenberger R, Eder S, Brown HA, Haemmerle G, Oberer M, Lass A, Kershaw EE, Zimmermann R, Zechner R. (2012). Adiponutrin (PNPLA3) functions as a nutritionally regulated lysophosphatidic acid acyltransferase. Cell Metabolism 15: 691-702. PMC 3361708

Lord CC, Betters JL, Ivanova PT, Milne SB, Myers DS, Madenspacher J, Thomas G, Chung S, Liu M, Davis MA, Lee RG, Crooke RM, Graham MJ, Parks JS, Brasaemle DL, Fessler MB, Brown HA, Brown JM. (2012) CGI-58/ABHD5-Derived  signaling lipids regulate systemic inflammation and insulin action. Diabetes 61(2): 355-363. PMC 3266405

Scott SA, O'Reilly MC, Daniels JS, Morrison R, Ptak R, Dawson ES, Tower N, Engers JL, Engers DW, Oguin T, Thomas P, White L, Brown HA, Lindsley CW. (2012) Development of a selective, allosteric PLD1/2 inhibitor in a novel scaffold. Probe Reports from NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23762925

Scott SA, O'Reilly MC, Daniels JS, Morrison R, Ptak R, Dawson ES, Tower N, Engers JL, Engers DW, Oguin T, Thomas P, White L, Brown HA, Lindsley CW. (2012) Development of a selective , allosteric PLD2 inhibitor. Probe Reports from NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US). PMID 23762931


2011

Liu STH, Sharon-Friling R, Ivanova PT, Milne SB, Myers DS, Rabinowitz J, Brown HA, Shenk T. (2011) Synaptic vesicle-like lipidome of human cytomegalovirus virions reveals a role for SNARE machinery in virion egress. Proc. Natl. Acad. Sci. USA 108(31): 12869-12874. PMC 3150939

Gorden DL, Ivanova PT, Myers DS, McIntyre JO, VanSaun MN, Wright JK, Matrisian LM, and Brown HA. (2011) Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. PLoS ONE 6(8): e22775.doi:10.1371/journal.pone.022775. PMC 3153459

Norton LJ, Zhang Q, Saqib KM, Schrewe H, Anderson KE, Lindsley CW, Brown HA, Simon A., Rudge SA, and Wakelam MJO. (2011) PLD1, rather than PLD2, regulates phorbol ester-, adhesion dependent-, and Fcγ receptor stimulated reactive oxygen species production in neutrophils. J. Cell Science 124(Pt.12): 1973-1983. PMC 3104032

Kang DW, Park MH, Lee YJ, Kim HS, Lindsley CW, Brown HA, Min DS. (2011) Autoregulation of phospholipase D activity is coupled to selective induction of phospholipaseD1 expression to promote invasion of breast cancer cells. Int. J. Cancer 128(4): 805-816. PMID 20473892


2010

Milne SB, Tallman KA, Serwa R, Rouzer CA, Armstrong MA, Marnett LJ, Lukehart CM, Porter NA, and Brown HA. (2010) Capture and release of alkyne-derivatized glycerophospholipids using cobalt chemistry. Nature Chem. Biol. 6(3): 205-207. PMC 2822082

Shulga YV, Myers DS, Ivanova PT, Milne SB, Brown HA, Topham MK, Epand RM.(2010) Molecular species of phosphatidylinositol-cycle intermediates in the endoplasmic reticulum and plasma membrane. Biochemistry 49(2): 312-317. PMC 2805767

Callender HL, Horn MA, DeCamp DL, Sternweis PC, and Brown HA. (2010)  Modeling species-specific diacylglycerol dynamics in the RAW 264.7 macrophage. J. Theor. Biol. 262(4): 679-690. PMC 2822135

Ivanova PT, Milne SB, and Brown HA. (2010)  Identification of atypical ether-linked glycerophospholipid species in macrophages by mass spectrometry. J. Lipid Res. 511581-1590. PMC 3035522

Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill A, Raetz CRH, Russell D, Subramaniam S, Dennis EA. (2010) Subcellular organelle lipidomics in TLR-4-activated macrophages. J. Lipid Res51: 2785-2797. PMC 2918461

Quehenberger O, Armando AM, Brown HA, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S., Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E. Murphy RC, Barkley RM, Leiker TJ, Raetz CRH, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. (2010) Lipidomics reveals remarkable diversity of lipids in human plasma. J. Lipid Res. 51: 3299-3305. PMC 2952570

Klappe K, Dijkhuis A-J, Hummel I, van Dam A, Ivanova PT, Milne SB, Myers DS, Brown HA, Permentier H, Kok JW. (2010) Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1. Biochem. J. 430: 519-529. PMID 20604746

Lavieri R, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels S, Brown HA, Lindsley CW. (2010) Design, synthesis and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethylbenzamides: Discovery of an isoform selective small molecule phospholipase D2 (PLD2) inhibitor. J. Med. Chem. 53(18):6706-6719.PMC 3179181

Rebres RA, Moon C, DeCamp D, Lin KM, Fraser ID, Milne SB, Roach TIA, Brown HA, Seaman WE. (2010) Clostridium difficile Toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J. Leukoc. Biol87(6): 1041-1057. PMC 2872536

Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH Jr, Sullards MC, Wang E, Murphy RC, Raetz CR, Garrett TA, Guan Z, Ryan AC, Russell DW, McDonald JG, Thompson BM, Shaw WA, Sud M, Zhao Y, Gupta S, Maurya MR, Fahy E, Subramaniam S. (2010) A mouse macrophage lipidome. J. Biol. Chem. 285(51): 39976-39985. PMC 3000979


2009

Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, and Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chem. Biol. 5(2): 108-117. PMID19136975

Lewis JA, Scott SA, Lavieri RL, Buck JR, Selvy PE, Stoops SL, Armstrong MD, Brown HA, Lindsley CW. (2009) Design and synthesis of isoform-selective phospholipase D(PLD) inhibitors. Part I. Impact of alternative halogenated priviledged structures for PLD1 specificity. Bioorg. Med. Chem. Lett. 19(7): 1916-1920. PMID19268584

Lavieri R, Scott SA, Lewis JA, Selvy PE, Armstrong  MD, Brown HA, Lindsley CW. (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity. Bioorg. Med. Chem. Lett. 19(8): 2240–2243. PMID 19299128

Zeng X, Zheng X, Xiang Y, Plumley H, Jessen JR, Zhong TP, Solnica-Krezel L, and Brown HA. (2009) Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Develop. Biol. 328(2): 363-376. PMC2688691

Rappley I, Myers DS, Milne SB, Ivanova PT, LaVoie MJ, Brown HA, Selkoe DJ. (2009) Lipidomics profiling in mouse brain reveals differences between ages and genders with smaller changes associated with α-synuclein genotype.  J. Neurochem. 111(1): 15-25. PMC2752313

Burnum KE, Cornett DS, Puolitaival SM, Milne SB, Myers DS, Tranguch S, Brown HA, Dey SK, Caprioli RM. (2009) Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation. J. Lipid Res. 50(11): 2290-2298.  PMC 2759835

Holinstat  M, Preininger  AM, Milne SB, Hudson WJ, Brown HA, Hamm HE. (2009) Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates. Mol. Pharmacol. 76(2): 301-313.  PMC 2713123

Brown HA and Murphy RC. (2009)  Working towards an exegesis for lipids in biology. Nature Chem. Biol. 5(9): 602-606. PMID 19690530

Ivanova PT, Milne SB, Myers DS, and Brown HA. (2009) Lipidomics: a mass spectrometry based, systems level analysis of cellular lipids. Curr.  Opin. Chem. Biol. 13:526-531.  PMC 2787871

Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. (2009) Evidence that α-synuclein does not inhibit phospholipase D. Biochemistry 48(5): 1077-1083. PMC 2683767

Marlo JE, Niswender CM, Days EL, Bridges TM, Xiang Y, Rodriguez AL, Shirey JK, Brady AE, Nalywajko T, Luo Q, Austin CA, Williams MB, Kim K, Williams R, Orton D, Brown HA, Lindsley CW, Weaver CD, Conn PJ. (2009) Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity. Mol. Pharmacol. 75(3): 577-588. PMC 2684909

Lung M, Shulga YV, Ivanova PT, Myers DS, Milne SB, Brown HA, Topham MK, and Epand RM. (2009) Diacylglycerol kinase epsilon is selective for both acyl chains of phosphatidic acid or diacylglycerol.  J. Biol. Chem. 284(45): 31062-31073. PMC 2781506


 2008

Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL.(2008)  Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin. Cancer Res. 14(13): 4267-4274.  PMC 2759181

Sun Y, Fang, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong MD, Brown HA, Chen J. (2008)  Phospholipase D1 is an effector of Rheb in the mTOR pathway.Proc. Natl. Acad. Sci. USA 105(24): 8286-8291. PMC 2448829

Milne SB, Ivanova PT, Armstrong MD, Myers DS, Lubarda J, Shulga YV, Topham MK, Brown HA, Epand RM. (2008) Dramatic differences in the roles in lipid metabolism of two isoforms of diacylglycerol kinase. Biochemistry 47 (36): 9372-9379. PMC 2744458

Brown HA. (2008)  New mechanism for a classic folate inhibitor. Nat. Chem. Biol. 4(10):581-582. PMID 18800042


2007

Sud M, Fahy E, Cotter D, Brown A, Dennis E, Glass CK, Merrill AH,Jr., Murphy RC, Raetz CR,  Russell DW, Subramaniam S. (2007).LMSD: LIPID MAPS structure database.  Nucl. Acids Res. 35: D527-532. PMC 1669719

Callender HL, Forrester JS, Ivanova P, Preininger A, Milne S, and Brown HA. (2007) Quantification of diacylglycerol species from biological extracts by electrospray ionization mass spectrometry.  Anal. Chem. 79: 263-272. PMID 17194150

Rouzer CA, Ivanova PT, Byrne MO, Brown HA, and Marnett LJ. (2007)  Lipid Profiling Reveals Glycerophospholipid Remodeling in Zymosan-Stimulated Macrophages.  Biochemistry 46: 6026-6042.  PMID 17458939

Ivanova PT, Milne SB, Byrne MO, Xiang Y, and Brown HA. (2007) Glycerophospholipid identification and quantitation by electrospray ionization mass spectrometry.  Methods Enzymol. 432, Lipidomics and Bioactive Lipids: Mass spectrometry based lipid analysis.  Ed. by H. Alex Brown. Elsevier. pp. 21-57. PMID 17954212

Brown HA, Henage LG, Preininger AM, Xiang Y, and Exton JH. (2007) Biochemical Analysis of Phospholipase D. Methods Enzymol. 434, Lipidomics and Bioactive Lipids:  Lipids and Cell Signaling. Ed. by H. Alex Brown. Elsevier. pp. 49-87. PMID 17954242

Murphy SC, Fernandez-Pol, S, Chung PH, Murthy SN, Milne SB, Salomao M, Brown HA, Lomasney JW, Mohandas N, and Haldar K. (2007) Cytoplasmic remodeling of erythrocyte raft lipids during infection by the human malaria parasite Plasmodium falciparum.  Blood 15: 2132-2139. PMC 1976375


2006

Dennis EA, Brown HA, Deems RA, Glass CK, Merrill AH, Murphy RC, Raetz CR,  Shaw W, Subramaniam S, Russell DW, VanNieuwenhze MS, White SH, Witztum JL, and Wooley J. (2006) The LIPID MAPS Approach To Lipidomics. In volume Functional Lipidomics.  Ed. by L. Feng and G. D. Prestwich. CRC Press, Boca Raton, FL.

Milne SB, Forrester JS, Ivanova PT, Armstrong MD, and  Brown HA. (2006) Multiplexed Lipid Arrays of Antiimmunoglobulin M-Induced Changes in the Glycerophospholipid Composition of WEHI-231 Cells.  In volume:  Functional LipidomicsEd. by L. Feng and G. D. Prestwich. CRC Press, Boca Raton, FL.

Henage L, Exton J, and Brown HA. (2006) Kinetic analysis of a mammalian Phospholipase D: Kinetic analysis of a mammalian Phospholipase D: Allosteric modulation by monomeric GTPases, Protein kinase C and polyphosphoinositides. J. Biol. Chem. 281: 3408-3417. PMID 16339153

Preininger AM, Henage L, Oldham W, Yoon EJ, Hamm HE, and Brown HA. (2006) Direct modulation of phospholipase D activity by Gβγ. Mol. Pharmacol. 70: 311-318. PMID 16638972

Milne SB, Ivanova PT, Forrester JS, and Brown HA. (2006) Lipidomics: Analysis of cellular lipids by ESI-MS. Methods 39: 92-103.

Rouzer CA, Ivanova PT, Byrne MO, Milne SB, Marnett LJ, and Brown HA. (2006) Lipid profiling reveals arachidonate deficiency in RAW264.7 cells: Structural and functional implications. Biochemistry 45: 14795-14808. PMC 2443946


Earlier publications

Milne SB, Ivanova PT, DeCamp D, Hsueh RC, and Brown HA. (2005) A targeted mass spectrometric analysis of phosphatidylinositol phosphate species. J. Lipid Res. 46: 1796-1802. PMID 15897608

Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W., Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, Witztum J, and Dennis EA.  (2005)  A comprehensive classification system for lipids. J. Lipid Res. 46: 839-862. PMID 15722563

Forrester JS, Milne SB, Ivanova PT, and Brown HA.  (2004) Computational lipidomics:  A multiplexed analysis of dynamic changes in membrane lipid composition during signal transduction. Mol. Pharmacol. 65: 813-821. PMID 15044609

Ivanova PT, Milne SB, Forrester JS, and Brown HA. (2004) Lipid arrays: new tools in the understanding of membrane dynamics and lipid signaling. Mol. Interv. 4: 86-96. PMID 15087482

Walker SJ and Brown HA.  (2004) Measurement of G protein stimulated phospholipase D activity in intact cells.  Methods Mol. Biol. 237: 89-97. G Protein Signaling: Methods and Protocols.  Edited by A.V. Smrcka .Humana Press Inc., Totowa, NJ. PMID 14501041

Fang Y, Park I-H, Wu A-L, Du G, Huang P, Frohman MA, Walker SJ, Brown HA, Chen J.  (2003) PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.  Curr. Biol.13: 207-2044. PMID 14653992

Sieczkarski SB, Brown HA, Whittaker GR. (2003) Role of protein kinase C βII in influenza virus entry via late endosomes. J. Virology 77: 460-469. PMID 12477851

Ge M, Gidwani  A, Brown HA, Holowka D, Baird B, and Freed JH. (2003) Ordered and disordered phases coexist in plasma membrane vesicles of RBL-2H3 mast cells. An ESR study.  Biophys. J. 85: 1278-1288. PMID 1288567

Gidwani A, Brown HA, Holowka D, and Baird B. (2003) Disruption of lipid order by short chain ceramides correlates with direct inhibition of phospholipase D1 and downstream signaling by FcεRI.  J. Cell Science 116: 3177-3187. PMID 12829737

Gilman AG et al., (2002) Overview of the alliance for cellular signaling. Nature 420: 703-706. PMID 12478301

Walker SJ and Brown HA.  (2002)  Specificity of Rho insert-mediated activation of phospholipase D1.  J. Biol. Chem. 277: 26260-26267. PMID 12011045

Eisen S and Brown HA.  (2002)  Selective estrogen receptor modulators differentially regulate PLD catalytic activity in ER-negative breast cancer cells. Mol. Pharmacol. 62: 911-920. PMID 12237338

Brooks MB, Catalfamo JL, Brown HA, Ivanova PT, and Lovaglio J.  (2002)  A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity.  Blood 99: 2434-2441. PMID 11895776

Ivanova PT, Cerda BA, Horn DM, Cohen JS, McLafferty FW, and Brown HA. (2001) Electrospray ionization mass spectrometry analysis of changes in phospholipids in RBL-2H3 mastocytoma cells during degranulation.  Proc. Natl. Acad. Sci. USA. 98(13): 7152-7157. PMID 11416200

Ganley I, Walker SJ, Manifava M, Li D, Brown HA, Ktistakis NT. (2001)  Interaction of phospholipase D1 with a casein-kinase-2-like serine kinase.  Biochem. J. 354: 369-378. PMID 11171116

Cohen JS and Brown HA. (2001) Phospholipases stimulate secretion in RBL mast cells. Biochemistry 40: 6589-6597. PMID 11380253

Ge M, Cohen JS, Brown HA, and Freed JH. (2001) ADP ribosylation factor 6 binding to phosphatidylinositol 4,5-bisphosphate-containing vesicles creates defects in the bilayer structure: An ESR study.  Biophys. J. 81(2): 994-1005. PMID 11463641

Walker SJ, Wu WJ, Cerione RA, and Brown HA. (2000) Activation of phospholipase D1 by Cdc42 requires the Rho insert region.  J. Biol. Chem.  275: 15665-15668. PMID 10747870

Paradiso AM, Brown HA, Ye H, Harden TK, and Boucher RC. (1999)  Heterogeneous responses of cell Ca2+ in human airway epithelium.  Exp. Lung Res. 25: 277-290. PMID 10378100

Singer WD, Brown HA, and Sternweis PC. (1997)  Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Ann. Rev. Biochem.  66: 475-509. PMID 9242915

Ktistakis NT, Brown HA, Waters MG, Sternweis PC, and Roth MG. (1996) Evidence that phospholipase D mediates ADP ribosylation factor-dependent formation of Golgi coated vesicles. J. Cell Biol. 134: 295-306.

Singer WD, Brown HA, Jiang X, and Sternweis PC. (1996) Regulation of phospholipase D by protein kinase C is synergistic with ADP-ribosylation factor and independent of protein kinase activity. J. Biol. Chem. 271: 4504-4510.

Lazarowski ER, Watt WC, Stutts MJ, Brown HA, Boucher RC, and Harden TK. (1996) Enzymatic synthesis of UTPγS, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br. J. Pharmacol. 117: 203-209

Ktistakis N, Brown HA, Sternweis PC, and Roth MG. (1995) Phospholipase D is present on Golgi-enriched membranes and its activation by ADP ribosylation factor is sensitive to brefeldin A.  Proc. Natl. Acad. Sci. USA 92: 4952-4956.

Brown HA, Gutowski S, Kahn RA, and Sternweis PC. (1995) Partial purification and characterization of Arf-sensitive phospholipase D from porcine brain. J. Biol. Chem. 270: 14935-14943

Singer WD, Brown HA, Bokoch GM, and Sternweis PC. (1995) Resolved phospholipase D activity is modulated by cytosolic factors other than Arf. J. Biol. Chem. 270: 14944-14950.

Brown HA and Sternweis PC. (1995)  Stimulation of phospholipase D by ADP-ribosylation factor. In Meth. Enzymol. 257.  W.E. Balch, C.J. Der, and A. Hall, eds. Academic Press.  pp. 313-324

Brown HA, Gutowski S, Moomaw CR, Slaughter C, and Sternweis PC. (1993) ADP-ribosylation factor (ARF), a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75: 1137-1144.

Brown HA, Lazarowski ER, Boucher RC, and Harden TK. (1991) Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5'-nucleotide receptor in human airway epithelial cells.  Mol. Pharmacol. 40: 648-655.

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