The Brown laboratory is focused on cell signaling networks that initiate production of phosphatidic acid. This lipid second messenger has been shown to modulate numerous cell signaling cascades, cell survival pathways and membrane remodeling processes. Computational lipidomics is a systems biology based approach pioneered by our group. We use mass spectrometry to define lipid species involved in pathways relevant to cancer, inflammation, infectious diseases, and metabolic disorders. These pathways are subsequently evaluated as potential therapeutic targets.

Selvy, P.E., Lavieri, R., Lindsley, C.W., and Brown, H.A. "Phospholipase D - Enzymology, functionality, and chemical modulation" (2011) Chemical Reviews Chemical Reviews –Lipid Biochemistry, Metabolism and Signaling 111(10): 6064-6119. PMC 3233269

Milne SB, Tallman KA, Serwa R, Rouzer CA, Armstrong MA, Marnett LJ, Lukehart CM, Porter NA, and Brown HA. (2010) Capture and release of Alkyne-Derivatized Glycerophospholipids using cobalt chemistry. Nature Chemical Biology. 6(3):205-207. PMC 2822082

Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, and Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature Chemical Biology 5(2): 108-117. PMID 19136975


>> View All Publications and Reviews