Hannah Callender , M.S.,
Vanderbilt University

 

Hannah Callender is a Vanderbilt mathematics graduate student working with the Brown Lab to create mathematical models of cell signaling pathways. She will initially work on more focused components in cAMP and calcium pathways to investigate properties of monotonicity and stability of feedback loops within the signaling pathways. Monotonicity, along with a few mild conditions, is known to provide stability information for the system, and she will apply that knowledge to these signaling pathways. We hope to obtain more information on, for instance, the activity of transcription factors in response to second messengers such as calcium and cAMP. This information will be integrated with information derived from lipidomic analysis to better understand how changes in membrane lipid composition are integrated with other signaling pathways to regulate gene transcription and other regulatory outcomes that control cellular phenotype.