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Anita M. Preininger, Ph.D.,
Anita Preininger, Ph.D., is a postdoctoral associate that conducted her doctoral training in the laboratory of Dr. Heidi Hamm. Previous work focused on structural and functional aspects of G-protein signaling, specifically the role of the myristoylated amino terminus in G∝i proteins using fluorescence, EPR, and crystallographic techniques. In the Brown lab , Anita has taken on the difficult task of defining and eventually reconstituting the signaling transduction pathway from GPCRs to PLD. This includes use of Lipid Array-mass spectrometry to determine the differences in lipid signaling patterns between different subtypes of P2Y purinergic receptors expressed in a null cell background. Anita is also working with other members of the group and our colleagues in the Vanderbilt-Ingram Cancer Center to obtain lipid profiles in primary breast cancer cells in comparison to profiles in normal breast tissue. We are interested in elucidating roles of bioactive lipids in anchorage-independent growth and cell invasive properties of tumor cells. Anita also provides chemistry support and expertise to our colleagues interested in lipid trafficking and transport by helping to develop new assays and synthesizing synthetic compounds.
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